SRR8942973
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.300
- MYC_TARGETS_V1+0.160
- WNT_BETA_CATENIN_SIGNALING+0.150
- PANCREAS_BETA_CELLS+0.140
- TGF_BETA_SIGNALING+0.120
- UV_RESPONSE_DN+0.110
- ANDROGEN_RESPONSE+0.100
- HEME_METABOLISM+0.040
- OXIDATIVE_PHOSPHORYLATION+0.000
- UNFOLDED_PROTEIN_RESPONSE-0.030
Top 10 suppressed
- ANGIOGENESIS-0.460
- INTERFERON_ALPHA_RESPONSE-0.450
- IL6_JAK_STAT3_SIGNALING-0.430
- CHOLESTEROL_HOMEOSTASIS-0.420
- ESTROGEN_RESPONSE_LATE-0.410
- ALLOGRAFT_REJECTION-0.400
- COAGULATION-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- TNFA_SIGNALING_VIA_NFKB-0.390
- INFLAMMATORY_RESPONSE-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
5 twins match this tumor's tissue · 5 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202455 | — | — | 0.874 |
| 2 | SRR8942980 | — | — | 0.873 |
| 3 | DRR168565 | — | — | 0.869 |
| 4 | MDT-AP-3207 | Med | Medulloblastoma | 0.865 |
| 5 | MNG1181 | — | — | 0.865 |
| 6 | MDT-AP-0395 | Med | Medulloblastoma | 0.864 |
| 7 | MDT-AP-1341 | Med | Medulloblastoma | 0.858 |
| 8 | MDT-AP-2991 | Med | Medulloblastoma | 0.856 |
| 9 | BS_SDCNP7MW | EPN | EPN Tumor | 0.856 |
| 10 | TCGA-A7-A0DC-01A-11R-A00Z-07 | — | D | 0.855 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.300 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.160 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.150 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.140 | Cobimetinib | — uncovered |
| TGF_BETA_SIGNALING | 0.120 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.110 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.100 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.040 | Temsirolimus | — uncovered |