MNG1181
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.295
- PANCREAS_BETA_CELLS+0.174
- BILE_ACID_METABOLISM+0.102
- PROTEIN_SECRETION+0.072
- TGF_BETA_SIGNALING+0.067
- UV_RESPONSE_DN+0.066
- PEROXISOME+0.058
- MYC_TARGETS_V1+0.055
- NOTCH_SIGNALING+0.040
- FATTY_ACID_METABOLISM+0.009
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.467
- HYPOXIA-0.408
- COMPLEMENT-0.382
- MITOTIC_SPINDLE-0.368
- COAGULATION-0.359
- TNFA_SIGNALING_VIA_NFKB-0.355
- APOPTOSIS-0.342
- INTERFERON_ALPHA_RESPONSE-0.333
- INFLAMMATORY_RESPONSE-0.332
- GLYCOLYSIS-0.324
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | BS_SDCNP7MW | EPN | EPN Tumor | 0.876 |
| 2 | SRR8942973 | — | — | 0.865 |
| 3 | TCGA-37-4129-01A-01R-1100-07 | — | cohortSC | 0.859 |
| 4 | SRR8943008 | — | — | 0.852 |
| 5 | SRR10900001 | — | — | 0.851 |
| 6 | SAMN03290937 | — | — | 0.847 |
| 7 | C3N-03420 | — | cohortA1 | 0.842 |
| 8 | SRR8613727 | — | D | 0.841 |
| 9 | R247 | — | — | 0.840 |
| 10 | DRR168565 | — | — | 0.839 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.295 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.174 | Cobimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.102 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.072 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.067 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.066 | Inavolisib | — uncovered |
| PEROXISOME | 0.058 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.055 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.040 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.009 | Inavolisib | — uncovered |