SRR1096966
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.390
- SPERMATOGENESIS+0.300
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.171
- HEDGEHOG_SIGNALING+0.167
- PEROXISOME+0.116
- HEME_METABOLISM+0.085
- FATTY_ACID_METABOLISM+0.076
- KRAS_SIGNALING_DN+0.061
- ADIPOGENESIS+0.058
- ESTROGEN_RESPONSE_EARLY+0.024
Top 10 suppressed
- G2M_CHECKPOINT-0.411
- ANGIOGENESIS-0.383
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.380
- E2F_TARGETS-0.375
- INFLAMMATORY_RESPONSE-0.359
- INTERFERON_ALPHA_RESPONSE-0.343
- WNT_BETA_CATENIN_SIGNALING-0.329
- ALLOGRAFT_REJECTION-0.326
- TGF_BETA_SIGNALING-0.319
- NOTCH_SIGNALING-0.303
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR657587 | GTEX | — | 0.942 |
| 2 | SRR1397094 | GTEX | — | 0.942 |
| 3 | SRR1376597 | GTEX | — | 0.940 |
| 4 | SRR659899 | GTEX | — | 0.934 |
| 5 | SRR1353157 | GTEX | — | 0.934 |
| 6 | SRR600560 | GTEX | — | 0.931 |
| 7 | SRR657348 | GTEX | — | 0.928 |
| 8 | SRR1402900 | GTEX | — | 0.919 |
| 9 | SRR1322555 | GTEX | — | 0.915 |
| 10 | SRR655134 | GTEX | — | 0.915 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.390 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.300 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.171 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.167 | Inavolisib | — uncovered |
| PEROXISOME | 0.116 | Idelalisib | — uncovered |
| HEME_METABOLISM | 0.085 | Temsirolimus | — uncovered |
| FATTY_ACID_METABOLISM | 0.076 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.061 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.058 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.024 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.012 | Idelalisib | — uncovered |