SRR659899
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.446
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.211
- BILE_ACID_METABOLISM+0.202
- SPERMATOGENESIS+0.182
- FATTY_ACID_METABOLISM+0.175
- ADIPOGENESIS+0.174
- HEDGEHOG_SIGNALING+0.169
- HEME_METABOLISM+0.144
- PEROXISOME+0.134
- PROTEIN_SECRETION+0.101
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.507
- IL6_JAK_STAT3_SIGNALING-0.492
- ALLOGRAFT_REJECTION-0.489
- INFLAMMATORY_RESPONSE-0.461
- INTERFERON_GAMMA_RESPONSE-0.460
- ANGIOGENESIS-0.451
- G2M_CHECKPOINT-0.368
- E2F_TARGETS-0.339
- APOPTOSIS-0.326
- KRAS_SIGNALING_UP-0.323
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR657587 | GTEX | — | 0.966 |
| 2 | SRR655134 | GTEX | — | 0.960 |
| 3 | SRR1415895 | GTEX | — | 0.942 |
| 4 | SRR1385124 | GTEX | — | 0.937 |
| 5 | SRR1096966 | GTEX | — | 0.934 |
| 6 | SRR1353157 | GTEX | — | 0.933 |
| 7 | SRR1322555 | GTEX | — | 0.928 |
| 8 | SRR1339218 | GTEX | — | 0.927 |
| 9 | SRR600560 | GTEX | — | 0.923 |
| 10 | SRR657348 | GTEX | — | 0.921 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 14 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.446 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.211 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.202 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.182 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.175 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.174 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.169 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.144 | Temsirolimus | — uncovered |
| PEROXISOME | 0.134 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.101 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.097 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.073 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.016 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.008 | Inavolisib | — uncovered |