SRR650144
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.340
- P53_PATHWAY+0.290
- APICAL_SURFACE+0.250
- PI3K_AKT_MTOR_SIGNALING+0.130
- ESTROGEN_RESPONSE_LATE+0.100
- SPERMATOGENESIS+0.100
- INTERFERON_ALPHA_RESPONSE+0.070
- ESTROGEN_RESPONSE_EARLY+0.060
- DNA_REPAIR+0.030
- OXIDATIVE_PHOSPHORYLATION+0.000
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.550
- ANGIOGENESIS-0.460
- PROTEIN_SECRETION-0.400
- UV_RESPONSE_DN-0.380
- ADIPOGENESIS-0.350
- COAGULATION-0.350
- BILE_ACID_METABOLISM-0.310
- TGF_BETA_SIGNALING-0.310
- XENOBIOTIC_METABOLISM-0.300
- MYC_TARGETS_V1-0.290
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-NC-A5HQ-01A-11R-A26W-07 | — | cohortSQ1 | 0.755 |
| 2 | SRR650137 | — | — | 0.748 |
| 3 | SRR33532821 | — | D | 0.741 |
| 4 | 20050097.LumA | — | B | 0.739 |
| 5 | a3380ca6-6c65-4543-9bdf-957b26c1daaf | — | — | 0.735 |
| 6 | MDT-AP-0398 | Med | Medulloblastoma | 0.734 |
| 7 | SRR25617904 | — | B | 0.723 |
| 8 | MBCProject_4647_T0_RNA | — | B | 0.715 |
| 9 | SRR4195695 | — | — | 0.712 |
| 10 | SRR1313108 | — | B | 0.710 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.340 | Remibrutinib | — uncovered |
| P53_PATHWAY | 0.290 | Idelalisib | — uncovered |
| APICAL_SURFACE | 0.250 | Temsirolimus | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.130 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.100 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.070 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.060 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.030 | Idelalisib | — uncovered |