SRR1394799
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.123
- WNT_BETA_CATENIN_SIGNALING+0.115
- PI3K_AKT_MTOR_SIGNALING+0.093
- DNA_REPAIR+0.071
- UNFOLDED_PROTEIN_RESPONSE+0.064
- UV_RESPONSE_UP+0.044
- MITOTIC_SPINDLE+0.018
- MYC_TARGETS_V2+0.007
- ANDROGEN_RESPONSE+0.000
- PROTEIN_SECRETION-0.014
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.579
- INTERFERON_GAMMA_RESPONSE-0.470
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.439
- INFLAMMATORY_RESPONSE-0.430
- ALLOGRAFT_REJECTION-0.421
- KRAS_SIGNALING_UP-0.393
- ANGIOGENESIS-0.386
- COAGULATION-0.370
- IL6_JAK_STAT3_SIGNALING-0.353
- APOPTOSIS-0.329
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1361736 | GTEX | — | 0.950 |
| 2 | SRR1471417 | GTEX | — | 0.950 |
| 3 | SRR1490568 | GTEX | — | 0.950 |
| 4 | SRR1387072 | GTEX | — | 0.949 |
| 5 | SRR1464305 | GTEX | — | 0.949 |
| 6 | SRR1359367 | GTEX | — | 0.948 |
| 7 | SRR820468 | GTEX | — | 0.946 |
| 8 | SRR1331944 | GTEX | — | 0.946 |
| 9 | SRR1335377 | GTEX | — | 0.946 |
| 10 | SRR1440119 | GTEX | — | 0.945 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.123 | Remibrutinib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.115 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.093 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.071 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.064 | Idelalisib | — uncovered |
| UV_RESPONSE_UP | 0.044 | Idelalisib | — uncovered |
| MITOTIC_SPINDLE | 0.018 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.007 | Idelalisib | — uncovered |