SRR1376597
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.340
- HEDGEHOG_SIGNALING+0.227
- SPERMATOGENESIS+0.222
- KRAS_SIGNALING_DN+0.124
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.096
- PEROXISOME+0.050
- HEME_METABOLISM-0.024
- ESTROGEN_RESPONSE_EARLY-0.041
- APICAL_SURFACE-0.052
- MYOGENESIS-0.055
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.491
- ANGIOGENESIS-0.411
- E2F_TARGETS-0.409
- G2M_CHECKPOINT-0.398
- INTERFERON_GAMMA_RESPONSE-0.385
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.378
- IL6_JAK_STAT3_SIGNALING-0.371
- INFLAMMATORY_RESPONSE-0.342
- TGF_BETA_SIGNALING-0.324
- ANDROGEN_RESPONSE-0.305
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1474065 | GTEX | — | 0.961 |
| 2 | SRR600560 | GTEX | — | 0.958 |
| 3 | SRR1370619 | GTEX | — | 0.944 |
| 4 | SRR1353157 | GTEX | — | 0.943 |
| 5 | SRR1096966 | GTEX | — | 0.940 |
| 6 | SRR1322555 | GTEX | — | 0.939 |
| 7 | SRR1432123 | GTEX | — | 0.938 |
| 8 | SRR1478077 | GTEX | — | 0.935 |
| 9 | SRR1359192 | GTEX | — | 0.931 |
| 10 | SRR1477634 | GTEX | — | 0.930 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.340 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.227 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.222 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.124 | Remibrutinib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.096 | Inavolisib | — uncovered |
| PEROXISOME | 0.050 | Idelalisib | — uncovered |